TY  - BOOK
AU  - Gu,Xun
TI  - Statistical theory and methods for evolutionary genomics
T2  - Oxford biology
SN  - 9780199213269 (hardback)
AV  - QH438.4.S73 G8 2011
U1  - 572.8/38 22
PY  - 2011///
CY  - Oxford, New York
PB  - Oxford University Press
KW  - Genomics
KW  - Statistical methods
KW  - Evolutionary genetics
N1  - Includes bibliographical references (p. [223]-250) and index; 1. Basics in molecular evolution -- 2. Basics in bioinformatics and statistics -- 3. Functional divergence after gene duplication: statistical modeling -- 4. Functional divergence after gene duplication: applications and others -- 5. Phylogenomic expression analysis between duplicate genes -- 6. Expression between duplicate genes: genome-wide analysis -- 7. Tissue-driven hypothesis of genomic evolution -- 8. Gene pleiotropy and evolution of protein sequence -- 9. Modeling the genomic evolution of gene contents -- 10. Advanced topics in systems biology and network evolution
N2  - "Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics, statistical modelling and bioinformatics, and the procedure of phylogeny-based analysis. Statistical Theory and Methods for Evolutionary Genomics summarises the statistical framework of evolutionary genomics, and illustrates how statistical modelling and testing can enhance our understanding of functional genomic evolution. The book reviews the recent developments in methodology from an evolutionary perspective of genome function, and incorporates substantial examples from high throughput data in model organisms. In addition to phylogeny-based functional analysis of DNA sequences, the author includes extensive discussion on how new types of functional genomic data (e.g. microarray) can provide exciting new insights into the evolution of genome function, which can lead in turn to an understanding of the emergence of genome complexity during evolution"--
ER  -